Composition
Each 1 tablet contains
Sulfadiazine 1.0 gm
Trimethoprim 0.2 gm
Properties
- The combination of a diaminopyrimidine (Trimethoprim) with a sulfonamide (Sulfadiazine) inhibits sequential steps in the synthesis of folic acid and thus the purines required for DNA synthesis.
- The interference by Trimethoprim with recycling of tetrahydrofolic or dihydrofolic acid is probably responsible for the synergistic interaction of the combination.
Antimicrobial spectrum:
Cotrimed tablet is effective against both gram-positive and gram-negative pathogenic bacteria sensitive to Sulfadiazine-Trimethoprim combination including Actinomyces, Bordetella, Clostridium, Corynebacterium, Fusobacterium, Haemophilus, Klebsiella, Pasteurella, Proteus, Salmonella, Shigella and Campylobacter spp., as well as Escherichia coli, Streptococci, and Staphylococci.
Indications
Pre ruminant Calves not more than 4 weeks of age.
Cotrimed tablet is indicated for the treatment of:
- Salmonellosis in calves caused by Salmonella spp, especially S. typhimurium and S. Dublin
- Undifferentiated diarrhea caused by E .coli
- Bacterial pneumonia caused by Pasteurella multocida.
- Footrot caused by Fusobacterium necrophorum, Staphylococcus aureus, Escherichia coli and Actinobacterium pyogenes.
- Septicemic colibacillosis caused by E. coli.
- Bovine respiratory disease caused by Pasteurella multocida and Haemophilus sommi.
- Urinary tract infection and mixed aerobe-anaerobe infections caused by Escherichia coli, Staphylococcus, Klebsiella, Proteus, Streptococci and Enterobacter spp.
Target species
Pre ruminant Calves not more than 4 weeks of age.
Dosage instructions
Orally.
Calves:
- 1 tablet (bolus) / 40 kg bodyweight for 3-5 days.
Warnings & Precautions
- Care in renal impairment.
- Care with concurrent chloramphinicol, miconazole, phenylbutazone and procaine HCl .
Contra Indications
- Not used in animals with hypersensitivity to sulphonamides & Trimethoprim.
- Should not be used in case of severe hepatic impairment & blood dyscrasias.
- Do not use in calves with a functional rumen
Side Effects
None when used as the recommended doses.
Withdrawal time
28 days for calves
Storage condition
Store at temperature not exceeding 30°C in a dry place
Packaging
- Carton box containing (AL/transparent PVC) 2 stripes each of 4 tablets + inner leaflet.
- Carton box containing (AL/transparent PVC) 3 stripes each of 4 tablets + inner leaflet
- Carton box containing (AL/transparent PVC) 4 stripes each of 4 tablets + inner leaflet