TRIMETHOSTAR

TRIMETHOSTAR

Oral Suspension

Product description

Composition

Each 1 ml contains
Sulfadimethoxine             333.3 mg
Trimethoprim                        66.7 mg

Properties

  • Sulfadimethoxine appears in combination with Trimethoprim in a mixing ratio of 5 parts Sulfadimethoxine + 1 part Trimethoprim for usage. The effective mechanism of the combination is based on a blocking sequential effect of both substances in the bacterial folic acid metabolism. The combination has a super additive effective intensity and therefore permits a significant dose reduction of the individual components.
  • The effective range of the drug combination corresponds to the one of the sulfonamides. The effect therefore is against several Gram positive and Gram negative bacteria ( E. coli, Shigella-species, Klebsiella-species, Proteus vulgaris, Pasteurella-species, Staphylococci, Streptococci, Pneumococci, Salmonellae, and Actinomyces-species amongst others) as well as coccidiostatic against Eimeria-species

Indications

Horse and foal:

For treatment of infectious diseases, in the early stage of infection caused by Sulfadimethoxine- and Trimethoprim-sensitive pathogens:

Primary and secondary infections of :

  • The respiratory organs
  • The gastro-intestinal tract and
  • The urogenital system

Target species

Horse and foals

Dosage and Administration

Orally:
5 ml of Timethostar/100 kg body weight / day for 3 – 7 days, in chronic disease for at least 7 – 10 days.

Warnings & Precautions

  • Ensure sufficient fluid intake during treatment to avoid kidney damages caused by crystalluria.
  • Determine as accurately as possible the body weight and doses before treatment to avoid an under- and overdose

Contra Indications

  • Severe liver and kidney dysfunctions.
  • Damage to the hematopoietic system.
  • Hypersensitivity to sulfonamides or Trimethoprim.
  • Resistance to sulfonamides or Trimethoprim.
  • Diseases associated with strong decreased fluid intake or severe fluid loss.
  • Do not use in neonates.

Side Effects

  • In rare cases after oral administration, digestive disorders, allergic reactions, kidney and liver damages and blood disorders may appear.
  • In pointing to crystal precipitation symptoms (hematuria, crystalluria, renal colic, compulsive urination) the treatment should be discontinued immediately and fluid, possibly with the addition of sodium bicarbonate must be given.
  • In case allergic reactions appear, the veterinary medicine must be discontinued and it must be treated according to symptoms

Withdrawal time

Not used for animal producing meat or milk for human consumption

Storage condition

Store at temperature not exceeding 30ºC and used after opening for 50 days at temperature not exceeding 30ºC

Packaging

50, 100, 125, 200, 250, 300, 500 & 1000 ml.