SULPHADIMIDINE 33.3%

SULPHADIMIDINE 33.3%

SULPHADIMIDINE 33.3%

Injectable Solution

Product description

Composition

Each 100 ml contains
Sulphadimidine sodium                                35.8 gm
Equivalent to Sulphadimidine base       33.3 gm

Properties

  • Sulfadimidine is a member of the Sulphonamide group of antibiotics. It exerts its bacteriostatic effect by interfering with the biosynthesis of folic acid in susceptible bacteria. Sulfadimidine competes with paraminobenzoic acid for the enzyme dihydropterate synthetase
  • Sulfadimidine has been shown to be effective in vitro against the following bacterial species: Actinobacillus lignieresi, Bordetella bronchiseptica
    ,Escherichia coli, Mannheimia haemolytica, Salmonella dublin, Salmonella typhimurium.

Indications

Cattle & sheep:

  • Bacterial Pneumonia and Bovine Respiratory Disease Complex caused by Pasteurella spp.
  • Colibacillosis (Bacterial Scours) caused by Escherichia coli
  • Necrotic Pododermatitis (Foot Rot) caused by Fusobacterium necrophorum.
  • Calf Diphtheria caused by Fusobacterium necrophorum
  • Acute Metritis caused by Streptococcus spp.

Beef Cattle:

  • Acute Mastitis caused by Streptococcus spp.

Swine:

  • Porcine Colibacillosis (Bacterial Scours) caused by Escherichia coli;

Bacterial Pneumonia caused by Pasteurella spp.

Target species

Cattle, Sheep and Pigs

Dosage instructions

For Cattle, sheep, pigs

  • By subcutaneous or intravenous (preferred) injection,
  • Recommended initial dose rate is 0.6 ml of product per kilogram bodyweight for first day
  • Maintenance dose of 0.3 ml of product per kilogram bodyweight .The maximum period of treatment should be 5 days.

Warnings & Precautions

  • To minimise the risk of injection site tissue reaction following subcutaneous administration it is recommended that the dose be divided, administered at separate sites and well massaged
  • Due to likely variability (time, geographical) in the occurrence of resistant bacteria for sulfadimidine, bacteriological sampling and susceptibility testing are recommended
  • Adequate water must be available during period of treatment. Particular care must be taken in the case of animals suffering from renal damage

Contra Indications

  • In known cases of hypersensitivity to sulphonamides
  • In animals with severe liver damage or blood dyscrasias.
  • Not for use in sheep producing milk for human consumption

Side Effects

  • Therapeutic doses are relatively non-toxic, but agranulocytosis, haemolytic anaemia and avitaminosis-K have been reported following prolonged administration. Prolonged treatment should be avoided, especially in young stock.
  • Crystalluria may occur, particularly when urinary pH is low. Ensure adequate water intake during treatment.
  • Occasional local tissue reactions may occur following subcutaneous injection

Withdrawal time

Sheep & Cattle

  • Meat: 18 days

Cattle

  • Milk: 156 hours (6.5days)

Pigs

  • Meat: 42 days

Storage condition

Store at temperature not exceeding 30ºC and used after opening for 60 days at temperature not exceeding 30ºC.

Packaging

Glass vials : 10, 20 , 30 , 50 , 100 , 200 , 250 & 500 ml

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