Composition:

Each 100 gm contains
Colistin (as Colistin sulphate) 600 MIU=20GM

Properties:

• Colistin is a polypeptide antibiotic belongs to the class of polymyxins.
• Colistin has a bactericidal action on sensitive bacterial strains, by disorganization of their cytoplasmic membrane, leading to an alteration of cell permeability and thus to a loss of intracellular material.
• Colistin has a bactericidal power against a broad spectrum of Gram-negative bacteria, including enterobacteria and in particular Escherichia coli. Colistin has very little activity against Gram-positive bacteria and fungal organisms.
  Gram-positive bacteria, as well as some species of Gram-negative bacteria such as Proteus and Serratia, are naturally resistant to colistin.
  However, the acquisition of resistance of Gram-negative enteric bacteria to colistin is rare and can be explained by simple mutation.
• Colistin exhibits concentration-dependent activity against Gram-negative bacteria. Following oral administration, high concentrations are observed in the gastrointestinal tract, i.e., the target site, due to the low absorption of the substance.

Indications:

• Treatment and metaphylaxis of gastrointestinal infections due to non-invasive colistin-sensitive E. coli.
• The presence of the disease in the flock must be established before proceeding to metaphylatic treatment.

Target species

Calves, Lambs ,Pigs and Chickens

Dosage and Administration

For whole product

For calves, lambs and pigs:

• 1.70 gm product Med-Colistin 600 / 100 kg body weight daily for 3-7 consecutive days.

For chickens:

• 1.70 gm Med-Colistin 600 /10 litre for 3-7 consecutive days

Duration of treatment should be limited to the minimum time necessary for the treatment of the disease.
Treatment duration should not exceed 7 days.

Warnings & Precautions

Special warnings for each target species:

• Colistin exerts concentration-dependent activity against Gram-negative bacteria. Following oral administration high concentrations are achieved in the gastrointestinal tract, i.e. the target site, due to the poor absorption of the substance’ These factors indicate that a longer duration of treatment than the one indicated in dosage section leading to unnecessary exposure is not recommended.

Special precautions for use in animals:

• Do not use colistin as a substitute for good management practices.
• Colistin is a last resort drug in human medicine for treatment of infections caused by certain multi-drug resistant bacteria.ln order to minimize any potential risk associated with widespread use of colistin, its use should be limited to treatment or treatment and metaphylaxis of diseases, and should not be used for prophylaxis.
• Whenever possible, colistin should only be used based on susceptibility testing.
• Use of the product deviating from the instructions given in the insert may lead to treatment failures and increase the prevalence of bacteria resistant to colistin.

Contra Indications

Do not use in horses, particularly in foals, since colistin, due to a shift in the gastrointestinal microflora balance could lead to the development of antimicrobial associated colitis (Colitis X) typically associated with clostridium difficile, which may be fatal.

Withdrawal time

Calves:

• Meat: 14 days

Pigs:

• Meat: 7 days

Poultry & Lamb

• Meat: 1 day

Eggs:

• Zero days

Not permitted for use in animals producing milk for human consumption.

Storage condition

Store at temperature not exceeding 30ºC in a dry place and used after opening for 40 days when stored at temperature not exceeding 30ºC in a dry place and used immediately after reconstitution

Packaging

LDPE plastic bags contain 100, 150, 200, 250 and 500 gm inside easy open metal cans printed with data.