Composition

Each 100 ml contains:
Oxytetracycline HCL                                           5.4 gm
Equivalent to Oxytetracycline base            5.0 gm

Properties

• Oxytetracycline is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the aminoacyl-transfer RNA to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of amino acids to the elongating peptide chain, inhibiting protein synthesis.
• In vitro, oxytetracycline is active against a range of both Gram-positive and Gram-negative micro organisms including: Streptococcus spp., Staphylococcus spp., L. monocytogenes, M. haemolytica, H. parahaemolyticus and B. bronchiseptica.

Indications:

The product is indicated for use in Cattle, sheep, pigs, horses, dogs and cats in the treatment of infections caused by organisms sensitive to oxytetracycline.

• Atrophic rhinitis caused by Bordetella bronchiseptica, Mannheimia haemolytica and Pasteurella multocida.
• Navel/joint ill caused by Arcanobacterium pyogenes, E. coli or Staphylococcus aureus.
• Mastits caused by Corynebacterium pyogenes, E. coli, Staphylococcus aureus, Streptococcus agalactiae or Streptococcus uberis.
• Metritis caused by E. coli or Streptococcus pyogenes.
• Pasteurellosis and infections of the respiratory tract caused by Mannheimia haemolytica and Pasteurella multocida.
• Septicaemia caused by Salmonella dublin and Streptococcus pyogenes.
• Erysipelas caused by Erysipelothrix rhusiopathiae.

Target species

Cattle, sheep, pigs, horses, dogs and cats

Dosage & Administration

Route of administration :
Intramuscular or intravenous injection in large animals, subcutaneous or intramuscular injection in small animals

For whole product:
The recommended general dosage rate is 0.6 -2 ml of Oxy-Five /10 kg bodyweight once daily for 5 days.

• Horse: 1 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.
• Foal : 2 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.
• Cow: 0.6 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.
• Calf, Pig, Sheep and lamb: 1.6 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.
• Sow/boar: 1 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.
• Dog and Cat : 2 ml of Oxy-Five / 10 kg bodyweight once daily for 5 days.

Warnings & Precautions

• Maximum recommended dose at any one site: 20 ml. cattle; 10 ml sheep, pig.
• Repeat doses should be administered at different sites, and the sites massaged well after injection.
• Intravenous injections must be given slowly over a period of at least one minute.
• As with other tetracyclines, caution should be exercised in treating horses under stress.
• Caution in animals with hepatic or renal impairment.
• The use of tetracyclines during the period of tooth and bone development, including late pregnancy, may lead to discolouration.
• It is not recommended to administer bacteriostatic and bactericidal antibiotics concurrently.
• Not for intravenous administration in dogs or cats.

Contra Indications

Not to be administered to horses during concomitant therapy with corticosteroids

Side Effects

• A transient swelling may be observed following intramuscular administration in horses and subcutaneous administration in dogs.
• Photodermatitis may occur after treatment if exposure to intense sunlight occurs.

Withdrawal time

Cattle:

• Meat : 35 days
• Milk – 6 days

Sheep:

• Meat : 14 days
• Milk : Not to be used in sheep producing milk for human consumption

Pigs:

• Meat :14 days

Storage condition

Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30°C.

Packaging

Glass vials : 10, 30, 50, 100, 200, 250 & 500 ml .