IVERMECTIN SUPER

Injectable Solution

Product description

Each 100 ml contains:
Ivermectin 1.0 gm
Clorsulon 10.0 gm

Ivermectin is a member of the macrocyclic lactone class of endectocides and has a unique mode of action. It has broad and potent antiparasitic activity. It binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarisation of the nerve or muscle cell, resulting and paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels such as those gated by the neurotransmitter gamma-amino-butyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, that the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Clorsulon is a sulfonamide. Clorsulon is rapidly absorbed in the blood stream. It is bound to the erythrocytes and plasma which are ingested by the fluke. Clorsulon inhibits the glycolytic enzymes in the fluke and deprives it of its main source of metabolic energy source and dies

Ivermectin super is indicated for the treatment of mixed infestation of adult liver fluke and gastro-intestinal roundworms, lungworms, eye worms, and/or mites and lice
Gastrointestinal roundworms (adult and fourth-stage larvae): Ostertagia ostertagi (including inhibited larval stages), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Bunostomum phlebotomum , Oesophagostamum radiatum, Strongyloides apillosus (adult) ,Nematodirus spathiger (adult), Nematodirus helvetianus (adult), Trichuris spp (adult), Lungworms (adult and fourth-stage larvae), Dictyocaulus viviparous
Liver fluke (adult) Fasciola hepatica
Eye worms (adult): Thelazia spp
Warbles (parasitic stages): Hypoderma bovis, H. lineatum
Mange mites: Psoroptes bovis, Sarcoptes scabiei var. bovis
Sucking lice : Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.

Non- Lactating Cattle

By S/C injection only:

Divide doses in excess of 10 ml between different injection sites and use different sites to those used for other parenteral medications

A low incidence of soft tissue swelling at the injection site has been observed

Withdrawal time: 49 days.
Milk and milk by-products produced during treatment not intended for human consumption

Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30°C Store in temperature not exceeding 30°c.

Glass vials : 10, 30, 50, 100, 200, 250 & 500 ml