IVERMECTIN 1%

IVERMECTIN 1%

IVERMECTIN 1%

Injectable Solution

Product description

Composition

Each 100 ml contains:
Ivermectin                  1 gm

Properties

  • Ivermectin is a member of the macrocyclic lactone class of endectocides
  • Ivermectin acts by inhibiting nerve impulses. It binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the relevant parasites. Compounds of this class may also interact with other ligandgated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels. The macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood- brain barrier
  • Ivermectin is effective against a wide range of nematode species and developmental stages, but has no activity against trematodes or cestodes.
  • They are termed endectocides because they are also active against many ectoparasites.

Indications

Cattle :

For the treatment of gastrointestinal nematodes, lungworms, eyeworms, warble flies, mites and lice (as shown below) of beef and non- lactating dairy cattle:

  • Gastrointestinal worms (adults and 4th stage larvae): Ostertagia ostertagi ,Ostertagia lyrata, Haemonchusplacei, Trichostrongyluscolubriformis, Cooperia oncophora (adults), Cooperia punctata (adults), Cooperia pectinata (adults), Bunostomum phlebotomum , Oesophagostomum radiatum Lungworms (adult and 4th stage larvae) , Dictyocaulus viviparus
  • Eyeworms (adult): Thelazia spp.
  • Warble flies (parasitic stages): Hypoderma bovis, H. lineatum
  • Mites: Psoroptes ovis, Sarcoptes scabiei var. bovis
  • Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus

May also be used as an aid in the control of the mange mite Chorioptes bovis but complete elimination may not occur.
Treatment at the recommended dose rate prevents re-infection with Haemonchus placei, Cooperia oncophora, Cooperia pectinata and Trichostrongylus axei for 7 days after treatment, Ostertagia ostertagi and Oesophagostomum radiatum for 14 days after treatment and Dictyocaulus viviparus for 21 days after treatment.

Sheep :

For the treatment of psoroptic mange (sheep scab), gastrointestinal nematodes, lungworms and nasal bots of sheep :

  • Gastrointestinal roundworms (adults):Ostertagia circumcincta, Haemonchus contortus, Trichostrongylus axei , T. colubriformis and T. vitrinus , Cooperia curticei, Nematodirus filicollis Variable activity may be observed against Cooperia curticei and Nematodirus filicollis.
  • Lungworms: Dictyocaulus filaria (adults)
  • Mange mites: Psoroptes ovis
  • Nasal bot: Oestrus ovis (all larval stages)

Pigs:

For the treatment of gastro-intestinal nematodes, lungworms, lice and mange mites of pigs.

  • Gastro-intestinal worms (adult and fourth stage larvae): Ascaris sum, Hyostrongylus rubidus, Oesophagostomum spp., Strongyloides ransomi (adults).
  • Lungworms: Metastrongylus spp. (adults)
  • Lice: Haematopinus suis
  • Mange Mites: Sarcoptes scabiei var. suis 

Target species

Cattle, sheep and pigs.

Dosage & Administration

By S/C injection only:

Cattle & sheep :

1 ml Ivermectin 1% / 50 kg B.W.

Pigs:

1 ml Ivermectin 1% / 33 kg B.W

Warnings & Precautions

  • Not combine treatment with vaccination against lungworms. If vaccinated animals are to be treated, treatment should not be carried out within a period of 28 days before or after vaccination
  • In Cattle: To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine, it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites

Contra Indications

  • Do not use in lactating dairy cows and sheep producing milk for human consumption.
  • Do not use in non-lactating dairy cows, including pregnant dairy heifers or non-lactating dairy sheep within 60 days of calving/lambing.
  • Do not use in cases of known hypersensitivity to ivermectin.
  • Do not administer by the intravenous or intramuscular route

Side Effects

  • Transitory discomfort has been observed in some animals immediately following subcutaneous administration.
  • In cattle this may include jumping and rolling, but behaviour returns to normal after 15 minutes.
  • Soft tissue swelling and thickening of the skin at the injection site has been observed in treated animals.
  • Typically these reactions are transient and disappear within one to four weeks.

Withdrawal time

Meat and offal:

  • Sheep: 42 days
  • Cattle : 49 days.
  • Pigs : 28 days.

Storage condition

Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30°C .

Packaging

Glass vial : 10, 30, 50, 100 & 500 ml .

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