Endexonil

Endexonil

Endexonil

Solution for Injection

Product description

Composition:

Each 1 ml contains:

  • Moxidectin: 10 mg

Properties:

The primary mode of action of avermectins like moxidectin is to affect chloride ion channel activity in the nervous system of nematodes and arthropods. The drug binds to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. Avermectins also enhance the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. Avermectins are generally not toxic to mammals, since they do not have glutamategated chloride channels and these compounds do not readily cross the blood-brain barrier where mammalian GABA receptors occur.

Indications:

Cattle (Beef and Non-Lactating Dairy).

  • For treatment and control of gastrointestinal roundworms: Ostertagia ostertagi (adults, fourth-stage larvae, and inhibited larvae), Haemonchus placei (adults), Trichostrongylus axei (adults and fourthstage
    larvae), T. colubriformis (adults and fourth-stage larvae), Cooperia oncophora (adults), C. pectinate (adults), C. punctate (adults and fourth-stage larvae), C. spatulata (adults), C. surnabad (adults and fourth-stage larvae), Nematodirus helvetianus (adults), Oesophagostomum radiatum (adults and fourth-stage larvae), Trichuris spp. (adults); lungworms: Dictyocaulus viviparous (adults and fourth-stage larvae); grubs: Hypoderma bovis and H. lineatum; mites: Psoroptes ovis (P. communis var. bovis); lice: Linognathus vituli and Solenopotes capillatus; for protection of cattle from reinfection with D. viviparous and O. radiatum for 42 days after treatment, with H. placei for 35 days after treatment, and with O. ostertagi and T. axei for 14 days after treatment.Moxidectin has a persistent effect against Ostertagia for 5 weeks and against Dictyocaulus for 6 weeks..

Target Species:

Cattle (Beef and Non-Lactating Dairy).

Dosage instructions:

Route of administration:

Administer by subcutaneous injection

For Whole Product:

  • Cattle: 1 ml/50 kg live bodyweight as a single subcutaneous injection.

Warnings & Precautions:

  • Do not use in calves to be processed for veal.
  • It should not be used in newly born domestic animals.

Contra – Indications:

  • Do not use in female dairy cattle of breeding age.

Side Effects:

  • Adverse effects appear to nonexistent or minimal.

Withdrawal Time:

  • Meat and offal: 21 days.
  • Milk: Not for use in female dairy cattle of breeding age.

Storage condition:

Store at temperature not exceeding 30◦C and used after opening for 40 days when stored at temperature not exceeding 30 ◦C.

Packaging:

Carton box containing amber glass vial type II containing 10, 20, 30, 50, 100, 200, 250 &500 ml with red chlorobutyl rubber stopper capped with flip off aluminum cap with outer label + an insert leaflet.

 

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