Composition:

Each 1ml contains:

• Ketoprofen           300mg

Properties:

Ketoprofen, 2-(phenyl 3-benzoyl) propionic acid is a non-steroidal anti-inflammatory drug belonging to the arylpropionic acid group. Ketoprofen inhibits the biosynthesis of prostaglandins (PGE2 and PGF2a) without affecting the ratio of PGE2/PGF2a and thromboxanes. This mechanism of action results in its anti-inflammatory, anti-pyretic and analgesic activity. These properties are also attributed to its inhibiting effect on bradykinin and superoxide anions together with its stabilizing action on lysosomal membranes. The antiinflammatory effect is enhanced by the conversion of the (R)-enantiomer to (S)-enantiomer. It is known that the (S)-enantiomer supports the ant-inflammatory effect of ketoprofen.

Target species:

• Fattening cattle.

Indications:

Treatment for the reduction of pyrexia and dyspnoea associated with respiratory disease in combination with appropriate anti-infective therapy.

Dosage and Administration:

Route: Orally via drinking water.
For whole products:
1ml / 100 kg.bwt of the finished product.
Treatment should be given for one day. it can be continued for another 1-2 days after a risk/benefit assessment by the responsible veterinarian.

Warnings and precautions:

• Water intake of treated animals should be monitored to ensure adequate intake.
•  As ketoprofen may provoke gastrointestinal ulcerations, the use is not recommended in cases of PMWS (post-weaning multisystemic wasting syndrome) because ulcers are already frequently associated with this pathology.
• To reduce the risk of adverse reactions do not exceed the recommended dose or duration of treatment.
• When administering to very young animals it is necessary to adjust the dose accurately as well as to perform a close clinical follow-up.

Contraindications:

• Do not administer to suckling calves.
• Do not administer to fasting animals or animals with limited access to feed.
• Do not use in animals where there is the possibility of gastrointestinal alterations, ulceration or bleeding in order not to aggravate their situation.
• Do not use in dehydrated or hypovolemic or hypotensive animal due to the potential risk of increased renal toxicity.
• Do not use in animals suffering from cardiac, hepatic, or renal disease.-
• Do not use where there is evidence of blood dyscrasia.
• Do not use in animals with a history of hypersensitivity to ketoprofen, aspirin or any of the excipients.

Side effects :

• Serious adverse reactions of a gastric nature have very rarely been observed in weaning calves under sever stressful situations (transportation, dehydration, fasting, etc).
• Other cases in intensive farming have been related to forced fasting situations prior or during treatment.
• Transitory softening of feces may occur which, in any event, disappears during or at the end of the treatment.
• If side effects occur treatment must be stopped for the whole group and the advice of a veterinarian should be sought.

Withdrawal time :

Meat and offals:

• 24 hours.

Storage conditions:

• Store at a temperature not exceeding 30 ⁰C.

Packaging :

White plastic (HDPE) bottles contain 50, 100, 500 ml, 1 and 5 L solution with white HDPE plastic cap and LDPE plastic internal foam liner with outer label.