TOLFIMATE

TOLFIMATE

TOLFIMATE

Injectable Solution

Product description

Composition

Each 100 ml contains:
Tolfenamic acid                         4 gm

Properties

Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) is a non-steroidal anti-inflammatory drug (NSAID) belonging to the fenamate group. Tolfenamic acid exerts anti-inflammatory, analgesic and antipyretic activities. The anti-inflammatory activity of Tolfenamic acid is mainly due to an inhibition of cyclo-oxygenase and thus to a reduction in the synthesis of prostaglandins and thromboxanes, which are important inflammatory mediators.

Indications

An anti-inflammatory, antipyretic and analgesic agent indicated:-

Cattle:

  • As an adjunct in the treatment of acute mastitis, used in conjunction with antibacterial therapy
  • As an aid in the control of acute inflammation associated with bacterial respiratory disease, used in conjunction with antibacterial therapy.

Pigs:

  • As an adjunct in the treatment of Metritis, Mastitis, Agalactia syndrome, used in conjunction with antibacterial therapy

Target species

Cattle & Pig

Dosage & Administration

Cattle:

  • For use in bovine mastitis:
    • 1 ml Tolfimate / 10kg body weight as a single IV injection.
  • For use in bovine respiratory disease:
    • 1 ml Tolfimate / 20kg body weight by IV or SC injection.

Treatment may be repeated once after 48 hours. If a second injection is needed this should be given in the opposite side of the animal’s body.

Pigs:

  • 1 ml Tolfimate /20kg body weight as a single intramuscular injection, in the neck musculature

Warnings & Precautions

  • Do not exceed 20ml per intramuscular injection site.
  • Do not exceed the stated dose or the duration of treatment
  • Do not administer other NSAIDs concurrently or within 24 hours of each other
  • Avoid use in any dehydrated, hypovolaemic or hypotensive animal as there is a potential risk of increased renal toxicity.
  • Do not use in newborn domestic animals

Contra Indications

  • Not for IM administration in cattle.
  • Not for IV or SC administration in pigs.
  • Not for SC administration in dairy cows
  • Use is contra-indicated in animals suffering from cardiac, hepatic or renal disease.
  • Where there is the possibility of gastro-intestinal ulceration or bleeding.
  • Where there is evidence of hypersensitivity to the product.

Side Effects

Transient swelling and inflammation can occur at the injection site.

Withdrawal time

Pigs:

  • Meat: 3 days

Cattle:

  • Meat: Following I/V inj. : 3 days
  • Meat: Following S/C inj. : 7 days
  • Milk: 24 hours

Storage condition

Store at temperature not exceeding 30°C and valid to 35 days after opening under storage temperature not exceeding 30°C

Packaging

Glass vials : 10, 20 , 30, 50, 100, 250 ml & 500 ml

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