Composition
Each 100 ml contains:
Pyrilamine maleate 2.5 gm
Ephedrine hydrochloride 1.0 gm
Properties
- Pyrilamine maleate is antihistamines (H1-receptor antagonists) competitively inhibit histamine at H1 receptor sites. They do not inactivate, nor prevent the release of histamine, but can prevent histamine’s action on the cell. Besides their antihistaminic activity, these agents also have varying degrees of anticholinergic and CNS activity (sedation). Pyrilamine is considered to be less sedating and have fewer anticholinergic effects when compared to most other antihistamines.
- Ephedrine is a sympathomimetic agent with direct and indirect effects on adrenoreceptors. It has alpha and beta-adrenergic activity.
Indications
Histablock used for treatment of allergy and other conditions in which it is desirable to neutralize histamine.
Target species
Cattle, horse, sheep , Swine, Dogs and Cats
Dosage &Administration
For whole product:
For I/M or I/V injection use
Cattle, horse, sheep and Swine:
1 ml Histablock/ 45 kg body weight
Dogs and cats:
0.5 ml Histablock / 10 kg body weight
When used intramuscularly doses may be repeated every 2 hours if necessary.
Warnings & Precautions
- The use of Histablock should not supersede the use of other emergency drugs and the procedures.
- Avoid overdosage.
- Do not use in newborn domestic animals due to presence of benzyl alcohol in product as preservative
Contra Indications
hypersensitivity to any ingredients of the product
Side Effects
- Horses: CNS stimulation (nervousness, insomnia, convulsions, tremors, ataxia), palpitation, GI disturbances, CNS depression (sedation), muscular weakness, anorexia, lassitude and incoordination.
- Other treated animal: Not known
Withdrawal time
For cattle , sheep & swine( Meat: 7 days & Milk: 48 hours)
Storage conditions
Store at temperature not exceeding 30°C and valid after opening for 50 days in temperature not exceeding 30°C
Packaging
Glass vials : 10, 20, 30, 50, 100, 250 & 500 ml