Composition

Each 100 ml contains:
Dexamethasone sodium phosphate     0.264 gm
Equivalent to Dexamethasone base     0.200 gm

Properties

• Dexamethasone is corticosteroids for systemic use.
• Corticosteroids suppress the immunologic response by inhibition of dilatation of capillaries, migration and function of leucocytes and phagocytosis.
• Glucocorticoids have an effect on metabolism by increasing gluconeogenesis
• This preparation contains the sodium phosphate ester of dexamethasone, a fluoro-methyl derivative of prednisolone, which is a potent glucocorticoid with minimal mineralocorticoid activity.
• Dexamethasone has ten to twenty times the anti-inflammatory activity of prednisolone.

Indications

Horses, cattle, pigs, dogs and cats:

Treatment of inflammatory or allergic conditions.

Cattle:

Induction of parturition. Treatment of primary ketosis (acetonaemia).

Horses:

Treatment of arthritis, bursitis or tenosynovitis

Target species

Cattle, horses, pigs, dogs and cats.

Dosage instructions

For Whole Product
The product may be administered by I/V or I/M injection in horses, and by I/M injection in cattle, pigs, dogs and cats. The product may also be given by intra-articular injection in horses.

• For the treatment of inflammatory or allergic conditions:
  • Horses, cattle, pigs: .
    • 1.5 ml/50 kg body weight (I/V or I/M injection)
  • Dogs, cats:
    • 0.5 ml/10 kg

Doses may be repeated once at 24-48 hours intervals if required. Injection sites should be alternated

• For the treatment of primary ketosis in cattle (acetonaemia):
  • 1-2 ml / 100 kg body weight by I/M injection

• For the induction of parturition:
  • To avoid foetal oversize and mammary oedema in cattle. A single I/M injection 2 ml / 100 kg body weight after day 260 of pregnancy.

Parturition will normally occur within 48 – 72 hours. If calving does not occur within these periods the dose may be repeated

• For the treatment of arthritis, bursitis or tenosynovitis:
  • By intra-articular injection in the horse. Dose 1- 5 ml

These quantities are not specific and are quoted purely as a guide. Injections into joint spaces or bursae should be preceded by the removal of an equivalent volume of synovial fluid. Strict asepsis is essential

Warnings & Precautions

• Use of the product in horses could induce laminitis and therefore careful observations should be made during treatment
• Special care should be taken when the product is used in animals with a weakened immune system.
• When treating groups of animals, use a draw-off needle to avoid excessive broaching of the stopper. The maximum number of broaching should be limited to 50.
• Following intra-articular administration, use of the joint should be minimized for one month and surgery on the joint should not be performed within eight weeks of use of this route of administration.
• Do not use in newborn domestic animals due to presence of benzyl alcohol in product as preservative

Contra Indications

• Except in emergency situations, do not use in animals suffering from diabetes mellitus, renal insufficiency, cardiac insufficiency, hyperadrenocorticism or osteoporosis.
• Do not use in viral infections during the viraemic stage or in cases of systemic mycotic infections.
• Do not use in animals suffering from gastrointestinal or corneal ulcers, or demodicosis.
• Do not administer intra-articularly where there is evidence of fractures, bacterial joint infections and aseptic bone necrosis.
• Do not use in known cases of hypersensitivity to the active substance, to corticosteroids and to any other ingredient of the product.
• Do not use in the last two weeks of pregnancy.

Side Effects

Polydipsia, polyuria, polyphagia, hypokalaemia, calcinosis cutis, immunosuppression, delayed wound healing, gastro-intestinal ulceration, decreased milk yield in lactating cows, hepatomegaly

Withdrawal time

Cattle:

• Meat and offal: 8 days
• Milk: 72 hours

pigs:

• Meat and offal: 2 days

Horses:

• Meat and offal: 12 days

Storage condition:

Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30 °C.

Packaging

Glass vials :10, 30, 50, 100, 250 & 500 ml.